Cmmb403 midterm Exam Correctly Answered Latest

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Cmmb403 midterm Exam | Q&A Latest 2025/2026 | 100% PASS Holt-Oram - Answer -____ syndrome is a human disease w a developmental basis that causes forelimb and heart defects where radius is missing and theres a hole btw ventricles so oxygenated and deoxygenated blood mixes. It is caused by a mutation of ONE copy of the TBX5 gene that codes for a transcription factor TBX5 - Answer -the transcription factor that is mutated in Holt-Oram syndrome - is expressed in the forelimb and the heart (NOT the hind limb) one (haploinsufficient) - Answer -one/two copy/copies oft he TBX5 transcription factor minimum must be mutated for Holt-Oram syndrome to occur in babies haploinsufficiency - Answer -when on functional copy of a gene is not enough to provide sufficient protein for normal function- heterozygote loss of function mutations cause an abnormal phenotype when a gene is____. for example, TBX5 transcription factor gene is ____ or holt Oram syndrome is caused by this of TBX5 whole-mount in situ hybridization (WISH) - Answer -method used to tell where in an embryo a given gene is transcribed c - Answer -why is there never human patients w a homozygous loss of function mutation of TBX5?